CORTISONE (COMPOUND E), 24-HOUR URINE
Measurement of both Free Cortisol and Cortisone are useful in diagnosing patients with low-renin hypertension caused by apparent mineralocorticoid excess. This may be due to either an inherited defect in 11HSDB2 enzyme or an acquired inhibitor of the enzyme by such compounds as glycyrrhizic acid, a component of natural licorice.
Collect urine with 10 g boric acid or keep urine refrigerated during collection
Sample by 7th of the month; report after 2–3 weeks.