Measurement of both Free cortisol and Cortisone are useful in diagnosing patients with low-renin hypertension caused by apparent mineralocorticoid excess. This may be due to either an inherited defect in 11HSDB2 enzyme or an acquired inhibitor of the enzyme by such compounds as glycyrrhizic acid, a component of natural licorice.
Overnight fasting is preferred. Take sample between 8–10 a.m OR 4–6 p.m
Sample Daily by 4 pm; Report 2 days