Rheumatologist

Anti CCP is useful in diagnosing Rheumatoid arthritis and entities that may potentially be confused with Rheumatoid arthritis that are rheumatoid factor positive.

Ionized calcium provides a more physiologically accurate assessment of calcium especially in the presence of high protein concentrations, hyperparathyroidism and hypoparathyroidism.

This is a qualitative assay for sreening and identification of specific IgG autoantibodies against Extractable Nuclear Antigens in human serum. It aids in the diagnosis of certain Systemic Rheumatic diseases.

The detection of Myositis specific autoantibodies (MSAs) is essential in the diagnosis of autoimmune myositis. MSAs are directed against cytoplasmic or nuclear components involved in key regulatory intracellular processes including protein synthesis, translocation and gene transcription. The striking association between unique serological profiles and distinct clinical phenotypes suggests that target autoantigens may play a role in disease induction and propagation

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology marked by a symmetric, peripheral polyarthritis. Serum antibodies to Cyclic citrullinated peptides (Anti CCP) are now recognised to be a valuable marker of diagnostic and prognostic significance. ANA’s occur both in systemic and organ specific autoimmune diseases showing positivity in Rheumatoid arthritis. There is incremental value in testing for presence of both Rheumatoid factor (RF) and Anti CCP as some patients with RA are positive for RF but negative for Anti CCP and vice versa.

U1RNP antibody in combination with Smith antibody provides additional support for the diagnosis of SLE. A positive U1RNP antibody alone with the corresponding clinical history supports the diagnosis of Mixed connective tissue disease.